Premium
Genetic Control of Contact Hypersensitivity
Author(s) -
Ishii Norihisa,
Ikezawa Zenro,
Nagai Ryukichi,
Tani Kenji,
Ishigatsubo Yoshiaki,
Okuda Kenji
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00007.x
Subject(s) - suppressor , antigen , biology , delayed hypersensitivity , microbiology and biotechnology , cell , dinitrophenyl , receptor , immunology , gene , antibody , biochemistry
The characteristics of suppressor cells induced by 2,4‐dinitrophenyl (DNP)‐coupled syngeneic lymphocytes (syninduced suppressor cells) were studied. 2,4‐dinitro‐1‐fluorobenzene (DNFB) contact hypersensitivity was completely suppressed when the syninduced suppressor cells were transferred intravenously. These syninduced suppressor cells had surface markers of Thy‐1, FcR − and Lyt‐2 + , 3 + antigens, as well as I‐J gene products on their cell surfaces. The suppression of DNFB contact hypersensitivity was abrogated when these suppressor T cells were incubated in Petri dishes coated with the DNP‐syngeneic lymphoid cell membrane, which suggests that these suppressor T cells had the specific antigen‐binding receptors on their cell surfaces.