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Macrophage Activation by Muramyl Dipeptide (MDP) without Lymphocyte Participation
Author(s) -
Nagao Shigeki,
Miki Tomohiro,
Tanaka Atsushi
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00005.x
Subject(s) - muramyl dipeptide , macrophage , lipopolysaccharide , lymphokine , macrophage activating factor , biology , lymphocyte , immunology , lymphocyte activation , microbiology and biotechnology , biochemistry , immune system , in vitro , t cell
An increase in the numbers of spread macrophages caused by macrophage stimulants was found to be a very sensitive measure for macrophage activation. Muramyl dipeptide (MDP), bacterial lipopolysaccharide (LPS), and lymphokines were found to activate macrophages dose‐dependently as measured by this parameter. Macrophage activation by MDP was strictly dependent on its adjuvant‐active stereochemically specific structures. Macrophage activation by MDP and LPS occurred without lymphocyte participation. It is suggested that LPS also activates macrophages via lymphocytes.