z-logo
Premium
Microbial Adjuvant and Autoimmunity
Author(s) -
Yamaki Kenichi,
Ohta Michio,
Nakashima Izumi,
Noda Aiji,
Asai Junpei,
Kato Nobuo
Publication year - 1980
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1980.tb02900.x
Subject(s) - pancreas , biology , cellular infiltration , infiltration (hvac) , mononuclear cell infiltration , pathology , connective tissue , autoimmunity , pancreatic islets , adjuvant , pancreatitis , antigen , islet , medicine , endocrinology , immunology , immune system , diabetes mellitus , inflammation , physics , thermodynamics
Definite lesions in the exocrine pancreas were produced when SMA mice were immunized eight times at intervals of 30 days with a mixture of extract of pooled pancreas from syngeneic mice and the capsular polysaccharide of Klebsiella pneumoniae type 1 Kasuya strain (CPS‐K), whereas no pancreatic lesions were produced in mice given CPS‐K alone or pancreatic extract alone. The typical histological changes were characterized by infiltration with lymphocytes, plasma cells, and other mononuclear cells, degeneration and lysis of the acinar cells, destruction of the lobular architecture, and replacement by fatty tissue and fibrous connective tissue. The endocrine islets were well preserved. No specific histological changes were produced in the organs other than the pancreas in these mice. Most of mice immunized with pancreatic extract mixed with CPS‐K produced serum precipitins to syngeneic pancreatic antigens. However, severe pancreatic lesions were also produced in mice showing no definite precipitin production.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here