Premium
Adjuvant Action of Capsular Polysaccharide of Klebsiella pneumoniae on Antibody Response
Author(s) -
Yokochi Takashi,
Nakashima Izumi,
Kato Nobuo,
Asai Junpei,
Iijima Soichi
Publication year - 1980
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1980.tb02899.x
Subject(s) - spleen , lymph node , adjuvant , klebsiella pneumoniae , infiltration (hvac) , bone marrow , biology , lipopolysaccharide , lymph , lymphatic system , antibody , pathology , polysaccharide , immunology , microbiology and biotechnology , medicine , escherichia coli , biochemistry , physics , gene , thermodynamics
The sequence of histological changes in the regional lymph node and other lymphoid organs of mice injected with the capsular polysaccharide of Klebsiella pneumoniae (CPS‐K) or bacterial lipopolysaccharide (LPS) was followed. Injection of CPS‐K, but not LPS, induced the following characteristic histological changes in the regional lymph node. In the early stage there was a marked decrease in the number of small lymphocytes, accompanied by the appearance of scattered fragmented nuclei and infiltration of polymorphonuclear neutrophilic leukocytes, and in the late stage there was marked proliferation of macrophage‐like cells and pyroninophilic cells. Histological changes in the thymus and spleen and changes in cell populations in the bone marrow and peripheral blood after CPS‐K injection were essentially the same as after LPS injection. Since CPS‐K has a much stronger adjuvant action on antibody response than does LPS, it is suggested that the characteristic histological changes in the regional lymph node after injection of CPS‐K are closely related to its extraordinarily strong adjuvant action.