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Hydrocephalus in Suckling Rats Infected Intracerebrally with Mouse Hepatitis Virus, MHV‐A59
Author(s) -
Hirano Norio,
Goto Naoaki,
Ogawa Tetsuo,
Ono Katsuhiko,
Murakami Toshiaki,
Fujiwara Kosaku
Publication year - 1980
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1980.tb02887.x
Subject(s) - mouse hepatitis virus , titer , cerebral cortex , virus , virology , biology , cerebrospinal fluid , hydrocephalus , inoculation , immunofluorescence , pathology , immunology , medicine , antibody , endocrinology , infectious disease (medical specialty) , neuroscience , disease , radiology , covid-19
After intracerebral inoculation of mouse hepatitis virus, MHV‐A59 strain, into 3‐ to 5‐day‐old Wistar rats, some survivors at 14 days postinoculation (p.i.) were found to lack the cerebral cortex and to have an accumulation of a considerable amount of cerebrospinal fluid. The virus titer in the brain increased exponentially after inoculation, reaching a maximum 4 to 6 days p.i. when immunofluorescence revealed virus‐specific antigen within neurons in the cerebral cortex. A small amount of infectious virus was also detectable 14 days p.i. when the cerebral anomaly was evident. This brain malformation causing hydrocephalus was due to cerebral damage by viral infection.