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Macrophage Activation by Muramyl Dipeptide as Measured by Macrophage Spreading and Attachment
Author(s) -
Tanaka Atsushi,
Nagao Shigeki,
Imai Katsuyuki,
Mori Ryoichi
Publication year - 1980
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1980.tb02858.x
Subject(s) - muramyl dipeptide , macrophage , lipopolysaccharide , lymphokine , macrophage activating factor , biology , thymidine , microbiology and biotechnology , immunology , biochemistry , in vitro
A synthetic bacterial cell wall constituent, muramyl dipeptide (MDP), was found to induce the enhancement of macrophage spreading and attachment on glass or plastic surfaces. Macrophages exposed to bacterial lipopolysaccharide or lymphokine‐containing cell supernatants showed similar enhancement. This finding supports the view that MDP activates macrophages. MDP was also found to enhance the viability of macrophages but to inhibit 3 H‐thymidine incorporation by macrophages.