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Properties of a Macrophage Cell Line Transformed by Simian Virus 40
Author(s) -
Katsumoto Tetsuo,
Takayama Hisao
Publication year - 1980
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1980.tb00581.x
Subject(s) - biology , simian , pseudopodia , clone (java method) , virus , macrophage , cell culture , virology , antigen , protein filament , microbiology and biotechnology , actin , immunology , gene , genetics , in vitro
A mouse macrophage clone (line NH‐1) transformed by simian virus 40 (SV40) was examined by electron microscopy. In the growing phase of the cultures, NH‐1 cells were non‐phagocytic and SV40 T antigen‐positive, and contained a large number of filament sheaths within their pseudopodia. In the late stationary phase, they became phagocytic, SV40 T antigen‐negative and contained a filamentous network within their psudopodia. In addition, NH‐1 cells in the late stationary phase were very similar to normal macrophages in other morphological properties.