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Interaction between 30 S Ribosomal Components in a Viomycin Resistant Mutant of Mycobacterium smegmatis
Author(s) -
Mizuguchi Yasuo,
Suga Kiyoko,
Yamada Takeshi
Publication year - 1979
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1979.tb00500.x
Subject(s) - mycobacterium smegmatis , viomycin , biology , mutant , microbiology and biotechnology , ribosomal rna , genetics , mycobacterium tuberculosis , gene , antibiotics , medicine , tuberculosis , pathology , streptomycin
A high level viomycin resistant mutant of Mycobacterium smegmatis ATCC 14468 (AC16) was analyzed genetically and biochemically in an attempt to understand the mechanisms of expression of high level viomycin resistance and co‐resistance to kanamycin and streptomycin. Genetic analysis has shown that at least three different genes ( vicC, str , and kan ) were involved in the phenotypic expression of drug resistance in AC16, and high level resistance to viomycin was due to interactions between the products of these genes.