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Effect of Certain Inhibitors of Glycoprotein Synthesis on Cell Fusion Induced by Vesicular Stomatitis Virus
Author(s) -
Takehara Manabu
Publication year - 1979
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1979.tb00453.x
Subject(s) - vesicular stomatitis virus , glycoprotein , biology , virus , cell fusion , virology , baby hamster kidney cell , cell , cell culture , glucosamine , vesicular stomatitis , microbiology and biotechnology , biochemistry , genetics
The effect of certain metabolic inhibitors on the fusion of BHK‐21 cells induced by vesicular stomatitis virus (VSV) was studied. The polykaryocyte formation in infected cells and virus growth were inhibited by 2‐deoxy‐ D ‐glucose and D ‐glucosamine. Host‐cell proteins ynthesis was suppressed profoundly in both BHK‐21‐KB and B cells infected with VSV. On the other hand, glycoprotein synthesis was significantly enhanced during the polykaryocyte formation in BHK‐21‐KB cells, while it was suppressed in BHK‐21‐B cells which were not sensitive to cell fusion by VSV.