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Genetic Control of Granuloma Response to Oil‐Associated BCG Cell Wall Vaccine in Mice
Author(s) -
Yamamoto KenIchi,
Kakinuma Mitsuaki
Publication year - 1978
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1978.tb00378.x
Subject(s) - biology , granuloma , immunology , major histocompatibility complex , strain (injury) , locus (genetics) , lung , immune system , gene , genetics , medicine , anatomy
Intravenous injection of mice with BCG cell wall vaccine induces granuloma in the lung. The granuloma induced as measured by lung weight showed marked strain differences; C3H/HeMs bred in this Institute (C3H), C3HeB/FeJ, P/J and A/He were low responders, whereas C57BL/6 and AKR/He were high responded. When C57BL/6 and C3H were compared, the responsiveness appeared to be inherent in each strain of mice providing strong evidence for genetic control in this phenomenon. Breeding experiments suggested that multiple loci, including a MHC‐linked locus, were involved although the role of the MHC‐linked loci was marginal.