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Common Antigen between Coxsackievirus A 16 and Enterovirus 71
Author(s) -
Hagiwara Akio,
Tagaya Isamu,
Yoneyama Tetsuo
Publication year - 1978
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1978.tb00351.x
Subject(s) - complement fixation test , precipitin , antigen , biology , immunodiffusion , antigenicity , virology , enterovirus , coxsackievirus , antibody , ouchterlony double immunodiffusion , virus , immunofluorescence , microbiology and biotechnology , antiserum , immunology , serology
Cross immunofluorescence revealed that coxsackievirus A 16 (CA 16) shared a common antigen with enterovirus 71 (E 71). The cross reactivity of these two serotypes was also examined by complement fixation test with purified virus preparations fractionated by sucrose density gradient centrifugation and two peaks of antigenicity were detected, one being type‐specific and the other cross‐reacting. The common antigen was heat‐stable and attributable to empty capsids. Immunodiffusion also revealed the common antigen. Infants without antibody to E 71 developed complement fixing and precipitin antibody to E 71 after recovery from hand, foot and mouth disease caused by CA 16.