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Antibacterial and Inducer Activities for Tetracycline Resistance by Its Derivatives and Analogues
Author(s) -
Inoue Matsuhisa,
Kazawa Toshio,
Mitsuhashi Susumu
Publication year - 1977
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1977.tb02808.x
Subject(s) - inducer , staphylococcus aureus , tetracycline , antibacterial activity , biology , microbiology and biotechnology , antibacterial agent , staphylococcus , plasmid , antibiotics , bacteria , biochemistry , genetics , gene
Antibacterial and inducer activities of thirteen TC derivatives were investigated for tetracycline (TC) resistance in staphylococcus aureus . Four compounds of the TC derivatives were not able to induce the resistance to TC in Staphylococcus aureus MS3937 r ms7 (TC) + harboring an inducible TC resistance determinant located on a plasmid. The 12a‐hydroxy position seems to be essential for the inducer activity.