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Ineffectiveness of Lipopolysaccharide for Preventing the Tolerance Induction in Bone Marrow‐Derived Lymphoid Cells with Dinitrophenyl‐Poly‐l‐(Glutamic Acid, Lysine)
Author(s) -
Uchiyama Takehiko,
Yamaura Noboru
Publication year - 1976
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1976.tb01008.x
Subject(s) - dinitrophenyl , lipopolysaccharide , lysine , bone marrow , chemistry , glutamic acid , lymphatic system , immunization , cell , microbiology and biotechnology , amino acid , immunology , biochemistry , antigen , antibody , medicine , biology
ABSTRACT The effect of endotoxin or lipopolysaccharide (LPS) on tolerance induction in bone marrow‐derived lymphoid cells (B cells) was investigated. Dinitrophenylated amino acid copolymer‐l‐(glutamic acid, lysine) (DNP‐GL) acts as a potent tolerogen on normal and DNP‐primed B cells. LPS significantly enhanced the anti‐sheep red blood cell plaque‐forming cell (anti‐SRBC PFC) response that occurred after the immunization with a low dose of SRBC. LPS did not induce the primary anti‐DNP PFC response after the injection of DNP‐GL, nor did it prevent the tolerance induction in normal and DNP‐primed B cells that occurred after the administration of DNP‐GL.