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Transition in the Character of Immunological Memory in Mice after Immunization
Author(s) -
Takaoki Muneo,
Kawaguchi Susumu,
Katsura Yoshimoto,
Muramatsu Shigeru
Publication year - 1976
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1976.tb00986.x
Subject(s) - antibody response , immunization , antibody , immunology , antigen , immunological memory , immune system , medicine , biology , immunity
The immunological memory in antibody response of mice to bovine serum albumin was investigated at the level of IgM and IgG antibody‐forming cells. The antigen at a dose much lower than required for eliciting a detectable level of the primary antibody response could latently activate the immune machinery to an extent adequate for specific recall, whereas higher doses of antigen were effective in evoking strong anamnestic response. The potentiality to develop the anamnestic response was found even in the latent phase of the primary antibody response and was maintained for more than 2 months. The immunological memory acquired in an early phase after the primary immunization mainly involved IgM antibody response and late memory concerned IgG response.