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Induction of Antiviral Activity In Vivo and In Vitro by Human Placenta Ribonucleic Acid Treated with Nitrous Acid
Author(s) -
Arimura Hirofumi
Publication year - 1976
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1976.tb00914.x
Subject(s) - rna , in vitro , in vivo , interferon , placenta , biochemistry , chemistry , biology , human kidney , microbiology and biotechnology , kidney , virology , fetus , gene , pregnancy , endocrinology , genetics
Induction of antiviral activity and interferon by human placenta ribonucleic acid deaminated with sodium nitrite (NO 2 ‐RNA) was studied in vitro and in vivo . (1) Viral multiplication in diploid cells from human kidney (HK cells) was depressed by pretreatment with NO 2 ‐RNA, but not by pretreatment with the original placenta RNA. (2) NO 2 ‐RNA showed an interferon‐inducing activity in rabbits and mice. (3) NO 2 ‐RNA sedimenting in 18 S and 28 S regions showed a higher antiviral activity than that sedimenting in 4 S region.