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The Effect of 2,4‐Dinitrophenol on the Growth of Bordetella pertussis in Chick Tracheal Organ Culture
Author(s) -
Iida Tsuyoshi,
Ajiki Yoko
Publication year - 1975
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1975.tb00895.x
Subject(s) - 2,4 dinitrophenol , bordetella pertussis , dinitrophenol , motility , microbiology and biotechnology , bacteria , bacterial growth , bordetella , metabolism , biology , organ culture , chemistry , biochemistry , in vitro , genetics
Among various metabolic inhibitors tested, only 2, 4‐dinitrophenol inhibited the growth of Bordetella pertussis in chick tracheal organ culture at concentrations nontoxic both for bacterial organisms and for ciliary motility of the tracheal fragments. Although this effect of 2, 4‐dinitrophenol was reversible in its early stage, longer treatment with this inhibitor resulted in an irreversible inhibition of bacterial growth due to secondary damage of the tracheal fragments. From these observations, it was postulated that the energy required for bacterial growth might be derived from cellular metabolism sensitive to inhibition with 2, 4‐dinitrophenol.