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Chemical and Immunological Studies on the Cell Walls of Propionibacterium acnes Strain C7 and Corynebacterium parvum ATCC 11829
Author(s) -
Azuma Ichiro,
Sugimura Kazuhisa,
Taniyama Tadayoshi,
Aladin Aminkham A.,
Yamamura Yuichi
Publication year - 1975
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1975.tb00880.x
Subject(s) - propionibacterium acnes , muramic acid , microbiology and biotechnology , corynebacterium , teichoic acid , cell wall , biochemistry , glucosamine , mannose , fatty acid , biology , propionibacterium , in vitro , chemistry , peptidoglycan , bacteria , genetics
The chemical and immunological properties of the cell walls prepared from the cells of anaerobic coryneforms, Propionibacterium acnes C7 and Corynebacterium parvum ATCC 11829, were partially investigated. The cell walls prepared from P. acnes C7 and C. parvum ATCC 11829 were composed of fatty acids, polysaccharides consisting glucose, galactose and mannose and mucopeptides consisting mainly of alanine, glutamic acid, a , ε‐diaminopimelic acid, glycine, muramic acid and glucosamine. As the fatty acid constituents of the cell wall of P. acnes C7, iso ‐pentadecanoic acid and iso ‐heptadecanoic acid were detected as major components. Both cell walls prepared from P. acnes C7 and C. parvum ATCC 11829 showed potent adjuvant activity on the formation of circulating antibody and development of delayed type hypersensitivity in vivo and on the primary immune response to sheep erythrocytes in vitro , however, could not augment helper function of carrier‐primed T cells and on the development of cell‐mediated cytotoxicity to mastocytoma P815‐X2 cells in C57BL/6J mice. It is also shown that the cell walls of P. acnes C7 and C. parvum ATCC 11829 act on mouse spleen cells as mitogen.