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Amoxycillin and Ampicillin
Author(s) -
Miller M.A.,
Kuemmerle N.B.,
Gentile G.
Publication year - 1975
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1975.tb00871.x
Subject(s) - ampicillin , minimum inhibitory concentration , minimum bactericidal concentration , microbiology and biotechnology , chemistry , amoxicillin , serratia marcescens , antibiotics , biology , escherichia coli , biochemistry , gene
In vitro antibacterial activities of ampicillin and amoxycillin were compared against pigmented and non‐pigmented strains of Serratia marcescens . Ampicillin appeared more effective than amoxycillin; three‐fourths of all strains consistently exhibited an ampicillin minimum inhibitory concentration (MIC) of at least one tube less than that recorded for amoxycillin. Complete cross resistance was not observed as has previously been inferred. Further, greater bactericidal activity was demonstrated with ampicillin; minimum bactericidal concentrations (MBC) were either the same as or one tube greater than the MIC. MBCs for amoxycillin, however, were significantly higher; often four to five times greater than the MIC. Ampicillin exhibited greater bactericidal activity as inferred from differences observed in the biological lesions induced, as recorded through observations by scanning electron microscopy (SEM). Spheroplasts were the predominant morphological alteration induced by ampicillin. In contrast, only filament formation, which demonstrated a degree of reversibility, was induced by amoxycillin.