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Staphylococcal Footpad Infection in Mice
Author(s) -
Katagiri Ken,
Hori Kenji,
Nishino Takeshi,
Fukao Takashi
Publication year - 1975
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1975.tb00853.x
Subject(s) - virulence , staphylococcus aureus , microbiology and biotechnology , inoculation , swelling , edema , staphylococcal infections , staphylococcus , intraperitoneal injection , bacteria , medicine , biology , immunology , pharmacology , pathology , biochemistry , genetics , gene
Local footpad infection in mouse was investigated with 55 clinically isolated strains of Staphylococcus aureus . When 10 7 viable cells were inoculated into the footpad, local swelling and bacterial growth resulted after 24 hr. With a dose of 10 6 cells, moderate swelling was observed after a few hours but the reaction had almost disappeared after 24 hr. About 75% of the staphylococcal strains tested caused footpad edema in mice at doses of 10 7 cells. A statistical comparison of the virulence of the organisms on intravenous and intraperitoneal injection with that in inducing footpad swelling is also reported.