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Antiinfluenzal Effect of Rugulosin
Author(s) -
Nakamura Shinichi,
Nii Fusako,
Inoue Satoru,
Nakanishi Isao,
Shimizu Masanao
Publication year - 1974
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1974.tb00736.x
Subject(s) - chorioallantoic membrane , inhalation , chemistry , virus , microbiology and biotechnology , virology , pharmacology , biology , in vitro , biochemistry , anatomy
(–)Rugulosin showed an antiinfluenzal effect in the allantoic cavity of chicken eggs as well as in cultured chorioallantois, proving itself to be more potent than 1‐adamantanamine. Also, (–)rugulosin, when administered by inhalation, was as effective for protection of mice against aerosol influenzal infection as orally administered 1‐adamantanamine. The effect of (–)rugulosin seemed to be mainly due to direct inactivation of influenza virus.