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The Role of Complement in Immune Phagocytosis of Group A Streptococci by Mouse Peritoneal Phagocytic Cells
Author(s) -
Saito Yuichi,
Horikawa Takahiro,
Kondo Wataru
Publication year - 1973
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1973.tb00931.x
Subject(s) - antibody opsonization , phagocytosis , microbiology and biotechnology , antibody , virulence , opsonin , immune system , in vitro , biology , properdin , complement system , virulence factor , group a , immunology , medicine , biochemistry , gene
The role of complement in ingestion of nonencapsulated virulent group A streptococci by mouse peritoneal phagocytic cells was studied in vitro in the presence of type‐specific IgG or IgM anti‐M antibody. Type‐specific IgG anti‐M antibody significantly enhanced the phagocytosis, whereas IgM antibody was less effective in opsonization of the virulent group A streptococci. The extent of phagocytosis of streptococci sensitized with IgG or IgM anti‐M antibody was not influenced by the presence of complement. These results suggested that complement was not an essential factor for efficient phagocytosis of virulent group A streptococci.