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Inhibition of Host Deoxyribonucleic Acid Synthesis after Infection of Ultraviolet‐Irradiated Measles Virus
Author(s) -
Minagawa Tomonori,
Nakaya Chikako,
Oguma Keizi,
Iida Hiroo
Publication year - 1973
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1973.tb00768.x
Subject(s) - measles virus , measles , pronase , antiserum , dna synthesis , ultraviolet light , virus , trypsin , virology , dna , proteolytic enzymes , biology , rna , microbiology and biotechnology , enzyme , ultraviolet irradiation , chemistry , antibody , biochemistry , irradiation , immunology , vaccination , photochemistry , gene , physics , nuclear physics
Measles virus suppressed cellular DNA synthesis two hours after infection but did not inhibit RNA or protein syntheses. The suppression of DNA synthesis was not dependent on the cellular growth phase but was dependent on the multiplicity of infection. This activity of measles virus was inactivated neither by ultraviolet‐irradiation nor by heating at 56 C for two hours, but was lost after treatment with a convalescent antiserum of a measles patient or with proteolytic enzymes (pronase and trypsin).