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Temperature‐Dependent Cellular Regulation in Induction of Cellular Deoxyribonucleic Acid Synthesis by Bovine Adenovirus Type 3
Author(s) -
Nakajima Katsuhisa,
Hamada Kokichi
Publication year - 1973
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1973.tb00716.x
Subject(s) - dna , microbiology and biotechnology , dna synthesis , clone (java method) , biology , cycloheximide , incubation , cell culture , chemistry , biochemistry , protein biosynthesis , genetics
Induction of cellular deoxyribonucleic acid synthesis by infection with bovine adenovirus type 3 was examined in 7 clones of a mouse cell line. Cellular DNA synthesis was induced by infection both at 37C and at 41C in 5 clones. In the other 2 clones, however, cellular DNA synthesis was induced only at 41C and not at 37C. In a clone non‐inducible at 37C, the incubation at 41C prior to infection resulted in induction of cellular DNA synthesis at 37C. The preincubation effect was not inhibited by cycloheximide during the incubation at 41C. In an other clone non‐inducible at 37C, the preincubation effect was not observed. The existence of a temperature‐dependent cellular factor(s) regulating the induction of cellular DNA synthesis was suggested.