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Field Trial with a Further Attenuated Live Measles Virus Vaccine
Author(s) -
Makino Satoshi,
Sasaki Keiko,
Nakamura Naoyoshi,
Nakagawa Masaharu,
Kasahara Shiro,
Mizunoe Kimifusa,
Hashimoto Takashi,
Ebihara Tutomu,
Nakazawa Susumu,
Oka Hide,
Sato Hazime,
Watanabe Osamu,
Niino Kenji,
Koga Fumiwaka,
Onuma Masayuki,
Kagami Kazuyuki,
Kimura Mikio,
Ishiguro Yoshio,
Yoshida Zengi,
Fugii Hiroshi
Publication year - 1973
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1973.tb00706.x
Subject(s) - seroconversion , virology , titer , measles , vaccination , measles vaccine , medicine , neutralizing antibody , yellow fever , measles virus , inoculation , virus , attenuated vaccine , antibody , immunology , biology , biochemistry , virulence , gene
A live measles virus vaccine was prepared with a virus strain attenuated by passage in the primary sheep kidney cell culture. All of 209 initially seronegative children showed seroconversion after subcutaneous inoculation of one dose of the vaccine. The geometric mean of neutralizing antibody titers following vaccination was 2 6.6 . Axillary temperature of 37.5 C or higher was recorded in 23.6% of 199 vaccinees with adequate clinical records, but only 4% had fever over 39.0 C. The average maximal temperature in feverish children was 38.3 C. Fever usually lasted for only one or two days. Neither febrile convulsion nor other toxic reactions was observed.