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Immune Response against Hamster Erythrocytes in the Low‐Responder Mouse Strains
Author(s) -
Nomoto Kikuo,
Yamada Hiroyasu,
Muraoka Shizuko,
Takeya Kenji
Publication year - 1973
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1973.tb00696.x
Subject(s) - hapten , immunization , antibody , hamster , antigen , booster dose , immune system , adjuvant , immunology , chemistry , microbiology and biotechnology , biology
The production of anti‐hapten antibody after immunization with trinitrophenylated (TNP) hamster erythrocytes (HRBC) or sheep erythrocytes (SRBC) was determined in high‐ and low‐responder mouse strains against HRBC antigen. 1) Anti‐TNP antibody was detected in sera of high‐responder DDD and CF1 mice after primary immunization with TNP‐HRBC, but not in those of low‐responder C57BL/6 mice. 2) Anti‐TNP antibody was detectable in sera of all the strains after primary immunization with TNP‐SRBC. 3) Production of anti‐TNP antibody was elicited after a booster injection of TNP‐HRBC in low‐responder C57BL/6 mice pre‐sensitized with HRBC in Freund's complete adjuvant. These results suggest that functions of thymus‐derived cells specific for HRBC antigen are deficient in low‐responder mice.