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Enhanced Synthesis of Phosphatidylethanolamine in Chick Embryo Cells Infected with Sendai Virus of Parainfluenza Type 1
Author(s) -
Shibuta Hiroshi,
Matumoto Minoru
Publication year - 1972
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1972.tb00647.x
Subject(s) - sendai virus , phosphatidylethanolamine , phosphatidylserine , ethanolamine , serine , embryo , biology , virus , chemistry , biochemistry , phosphatidylcholine , virology , phospholipid , microbiology and biotechnology , enzyme , membrane
3 H‐Serine principally labeled phosphatidylserine (PS) and phosphatidylethanolamine (PE) of lipids of chick embryo cells. 3 H‐Ethanolamine labeled almost entirely PE of lipids of the cells. In turnover experiment with 3 H‐serine incorporated into cells before infection, the pathway from PS to PE was shown to become more active by Sendai virus infection. Similar turnover experiment using 3 H‐ethanolamine revealed that PE synthesis directly utilizing ethanolamine was also slightly enhanced by the infection. The most marked difference of infected cells from control cells was the enhanced rate of 3 H‐serine incorporation into lipids. These results indicated that the Sendai virus infection enhanced the metabolic pathway serine–PS–PE.