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Immune Response against Hamster Erythrocytes in the Low‐Responder Mouse Strains
Author(s) -
Nomoto Kikuo,
Kuroiwa Ataru,
Takeya Kenji
Publication year - 1972
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1972.tb00636.x
Subject(s) - hemolysin , hamster , antibody , sensitization , booster dose , immune system , biology , lymphoma , strain (injury) , microbiology and biotechnology , inbred strain , immunology , immunization , chemistry , biochemistry , virulence , anatomy , gene
In a previous paper we reported that an inbred strain of SL mice and an outbred strain of CF1 mice belonged to the high‐responder strains in antibody production after primary immunization with hamster erythrocytes (H‐RBC), while inbred strains of C57BL/6, AKR and C3H/He mice belonged to low‐responder strains. In the present study we obtained the following results. 1) Pre‐sensitization with hamster lymphoma enhanced antibody production after an intravenous injection of H‐RBC. There was no strain difference in the pattern of antibody production against H‐RBC among pre‐sensitized mice. 2) The pattern of enhanced antibody production after an intravenous injection of H‐RBC into pre‐sensitized mice assumed the primary type in terms of time of appearance of hemolysin plaque‐forming cells (PFC) in the spleens and the conversion from 2‐mercaptoethanol sensitive to 2‐mercaptoethanol resistant antibody production, when the intervals between both treatments were within 7 days. 3) Pre‐sensitization with lymphoma induced not only an increase in numbers of PFC after an intravenous injection of H‐RBC, but also an increase in the size of the hemolysin plaques. These results suggested that sensitization with hamster lymphoma stimulated some kinds of immuno‐competent cells, which could contribute to antibody production against H‐RBC after a booster injection of H‐RBC.