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Interferon‐Inducing Activity of Acidic Polysaccharides
Author(s) -
Suzuki Shigeo,
Suzuki Masuko,
Imaya Masanori
Publication year - 1971
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1971.tb00609.x
Subject(s) - vesicular stomatitis virus , interferon , yeast , cytopathic effect , polysaccharide , microbiology and biotechnology , chemistry , homologous chromosome , virus , biology , biochemistry , virology , gene
Exocellular phosphomannans produced by four strains of Hansenula yeast were examined as to their interferon‐inducing activities in rabbits employing the assay system consisting of vesicular stomatitis virus and primary suckling rabbit kidney cells. The phosphomannan of Hansenula holstii NRRL Y‐2155 was shown to be the most potent inducer, and the interferon induced was highly host species‐specific, preventing viral cytopathic effects only in the homologous cells. The biological and chemical characteristics of the interferon closely resembled those of endotoxin‐induced interferon.