Premium
Drug‐Resistance and Distribution of R Factors among Proteus Strains
Author(s) -
Odakura Yoshihiro,
Tanaka Tokumitsu,
Mitsuhashi Susumu
Publication year - 1971
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1971.tb00593.x
Subject(s) - proteus , drug resistance , cephaloridine , microbiology and biotechnology , streptomycin , chloramphenicol , penicillin , kanamycin , shigella , tetracycline , ampicillin , biology , antibiotics , bacteria , cephalosporin , escherichia coli , genetics , salmonella , gene
Proteus strains were isolated in 1967 and 1968 from clinical specimens, and their drug resistance and distribution of R factors were investigated. With special reference to 4 drugs; tetracycline (TC), chloramphenicol (CM), streptomycin (SM), and sulfanilamide (SA), the surveys indicated that the isolation frequency of single TC‐resistance was the highest, followed by quadruple‐, triple‐, and double‐resistance in a decreasing order. It was the remarkable feature that the isolation frequency of R (TC.CM.SM.SA) factor was very low in Proteus strains in contrast to a large number of R (CM.TC.SM.SA) factors in Shigella strains. The isolation of 6 to 7‐drug resistance was the highest in P. rettgeri but that of 2 to 3‐drug resistance was much higher in other Proteus cultures. It should be noted that the isolation frequency of resistance to kanamycin (KM), ampicillin (APC) and cephaloridine (CER) was much higher than that in Shigella . Among the strains carrying resistance to the 3 drugs, the strains harboring resistance to both APC and CER were isolated most frequently (78.7%), followed by KM resistance (33.8%), CER resistance (10.8%), and others in a decreasing order. Thirty‐seven R factors were demonstrated from 171 strains examined. Although the TC resistance in Proteus strains included 86.6%, only one R factor carrying TC‐resistance marker, i.e., R (CM.TC.SM.SA.KM.APC.CER), was isolated. Namely, it indicated that most of the TC resistance in Proteus strains were found to be conjugally nontransmissible. By contrast, most of the KM resistance was conjugally transmissible.