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Studies on the Persistent Infection with Measles Virus in HeLa Cells
Author(s) -
Minagawa Tomonori
Publication year - 1971
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1971.tb00589.x
Subject(s) - vero cell , hela , measles virus , virus , virology , biology , viral culture , measles , cell culture , genetics , vaccination
HeLa cells were caused to degenerate by infection with the standard measles virus, while those infected with the virus released from the HeLa/MV culture (carried virus) readily established a carrier state. The carried virus had a longer latent period and a lower growth rate in both HeLa and Vero cell cultures as compared with the standard virus. Plaques by the carried virus on Vero cell cultures were delayed in appearance as compared with those by the standard virus. However, when the carried virus was passed once through Vero cells, the virus became able to form plaques as readily as the standard virus. Also the passed virus was found to have lost the ability to establish a carrier state. These results may suggest the possibility of a host‐controlled variation, though the mechanism of establishment of the HeLa/MV culture which harbors such a variant remains obscure.