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Drug Resistance of Staphylococci
Author(s) -
Kono Megumi,
O'Hara Koji,
Nagawa Masatoshi,
Mitsuhashi Susumu
Publication year - 1971
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1971.tb00573.x
Subject(s) - staphylococcus aureus , inducer , substituent , chloramphenicol , steric effects , moiety , chemistry , stereochemistry , drug resistance , staphylococcus , drug , antibiotics , microbiology and biotechnology , bacteria , biology , biochemistry , pharmacology , gene , genetics
Induction of chloramphenicol (CM) resistance in Staphylococcus aureus was investigated using 166 CM derivatives and analogues. It was found that 18 compounds of the samples used were able to induce resistance to CM in Staphylococcus aureus S1477 harboring an inducible CM‐resistance determinant. Most of the samples which had a nitrophenyl moiety and a D‐ or DL‐threo isomer in its steric configuration were found to have inducer activity for CM resistance. Competent inducers are D‐isomer CM derivatives which have another substituent in place of the hydroxyl group at carbon atom 3 in the propanediol of the drug.