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Relationship between Immunity and Interferon Production in Macrophages
Author(s) -
Azuma Masanobu,
Yamada Morihide,
Nishioka Rikichi
Publication year - 1970
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1970.tb00531.x
Subject(s) - antiserum , newcastle disease , interferon , virus , virology , immunity , chemistry , biology , microbiology and biotechnology , antibody , immune system , immunology
The effect of antiserum on the interferon (IF) production in macrophages by Newcastle disease virus (NDV) has been studied. Completely neutralized NDV lost its IF‐inducing ability, but under‐neutralized NDV revealed an enhanced IF‐inducing capability. This enhancement of IF production by unneutralized NDV was also observed in antiserum‐treated cells. Enhancement phenomena appeared to be based on immunological specificity. Under‐neutralized NDV was also adsorbed more rapidly and at a higher rate to normal cells than unneutralized NDV. Unneutralized NDV also adsorbed more efficiently to antiserum‐treated cells and to cells derived from immunized mice than to normal cells. The significance of these phenomena is discussed in relation to the induction mechanism of IF in macrophages.