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Heat‐Labile Virus‐Inhibiting Factor or Interferon Induced by Virus
Author(s) -
Maehara Nobutoshi,
Nagano Yasuiti
Publication year - 1970
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1970.tb00522.x
Subject(s) - virus , newcastle disease , interferon , inoculation , virology , microbiology and biotechnology , chemistry , biology , immunology
Stability to heat and acid of the virus‐inhibiting factor (IF) or interferon induced by viruses is generally accepted. Published data suggest, however, a heterogeneity in the virus‐induced IFs in their physico‐chemical and biological properties. The present work shows that the IF activity of rabbit serum collected 2 hr after intravenous inoculation with Newcastle disease virus is as labile as E. coli endotoxin‐induced IF when heated at 56C or dialysed at pH 2, whereas the serum‐IF at 6 hr is significantly more stable.