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Antigenic Determinants of Salmonella for Production of “Clearance” Factor in Mouse Typhoid
Author(s) -
Nakano Masayasu,
Saito Kazuhisa,
Toyasaki Norituna
Publication year - 1970
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1970.tb00503.x
Subject(s) - typhoid fever , microbiology and biotechnology , salmonella , virulence , antibody , typhoid vaccine , salmonella enteritidis , virulence factor , salmonella typhi , antigen , biology , immunization , peritoneal cavity , bacteria , virology , immunology , escherichia coli , biochemistry , genetics , anatomy , gene
The “clearance” factor produced in the peritoneal cavity of mice immunized with killed vaccines prepared from Salmonella typhimurium or S. enteritidis was identified as the specific antibodies elicited by the O side chain of the cell wall polysaccharides in the organisms used as immunogens. After immunization of mice with vaccines prepared from virulent Salmonella strains, complement‐dependent antibacterial antibodies in the serum and “clearance” factors in the peritoneal cavity were found to appear coincidentally, to last for more than one year, and to have the same specificity against the virulent bacterial strains. The relationship between the complement‐dependent antibacterial antibodies and “clearance” factor, and the mechanisms of bactericidal action of these antibacterial agents in experimental typhoid were discussed.