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Experimental Salmonellosis Immunizing Effect of Live Vaccine Prepared from Various Mutants of Salmonella Having Different Cell Wall Polysaccharides
Author(s) -
Kawakami Masaya,
Nakata Hisako,
Mitsuhashi Susumu
Publication year - 1969
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1969.tb00474.x
Subject(s) - microbiology and biotechnology , salmonella , lipopolysaccharide , virulence factor , virulence , mutant , polysaccharide , biology , salmonella enteritidis , immunization , virology , antibody , bacteria , gene , immunology , biochemistry , genetics
Immunizing potencies of vaccines prepared from various strains of Salmonella were graded by comparing the mortality rate of immunized mice after challenge with highly virulent strains of either Salmonella enteritidis or S. typhimurium . The resistance against this challenge infection was shown to be conferred by joint immunization with a specific factor, which was represented by O specific lipopolysaccharide of smooth strains, and cross‐protection factor, which was a major potent factor in live vaccine. The distribution of this cross‐protection factor in rough mutants of S. typhimurium was found to be limited to strains which possessed a polysaccharide chain longer than that of glucose 1 ‐less mutant. The potency conferring cross‐resistance was found to be maintained partly in formalin‐killed cells and cell walls of the strains harboring cross‐protection factor but not in lipopolysaccharide extracted from such strains.