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Biological Activity of Papain Digested Streptococcal Anti‐M Antibody
Author(s) -
Saito YÜIchi
Publication year - 1969
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1969.tb00432.x
Subject(s) - papain , antibody , opsonin , chemistry , in vitro , microbiology and biotechnology , in vivo , biological activity , biochemistry , biology , enzyme , immunology
Digestion of rabbit streptococcal anti‐M antibody with papain to produce univalent fragments resulted in the loss of its ability to fix complement. However, the digested univalent antibody still retained the indirect bactericidal activity in vitro , opsonic activity in vivo , and also the capability of protecting mice against the streptococcal infection. Thusly the biological activities of digested anti‐M antibody appear to be similar to those of intact anti‐M antibody.