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Drug Resistance of Enteric Bacteria
Author(s) -
Egawa Ryuki,
Sawai Tetsuo,
Mitsuhashi Susumu
Publication year - 1967
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1967.tb00334.x
Subject(s) - ampicillin , chloramphenicol , cloxacillin , sulfanilamide , streptomycin , microbiology and biotechnology , penicillin , tetracycline , escherichia coli , bacteria , drug resistance , amp resistance , antibiotics , sulfathiazole , biology , chemistry , biochemistry , genetics , gene
Five R factors capable of conferring resistance to ampicillin, together with resistance to 4 other drugs, tetracycline (TC), chloramphenicol (CM), streptomycin (SM) and sulfanilamide (SA), were found in Escherichia coli strains isolated from clinical sources. Ampicillin resistance was due to synthesis of penicillinase in the host bacterium which harbored the R factor. The penicillinases produced by three R factors were similar each other in their substrate specificity and were also similar to the enzyme reported by previous workers. The penicillinases produced by 2 other R factors were found to be greatly difierent from penicilhnases reported thus far. The latter were shown to hydrolyse ampicillin and cloxacillin efficiently, but penicillin‐G and 6‐aminopenicillanic acid to a lesser extent.