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Drug Resistance of Enteric Bacteria
Author(s) -
Harada Kenji,
Kameda Mitsuo,
Suzuki Mitsue,
Mitsuhashi Susumu
Publication year - 1967
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1967.tb00330.x
Subject(s) - transmissibility (structural dynamics) , salmonella , transduction (biophysics) , recombinant dna , microbiology and biotechnology , drug resistance , biology , bacteria , chemistry , genetics , gene , physics , biochemistry , vibration isolation , quantum mechanics , vibration
A nontransferable R 21 (TC) factor was obtained by transduction of R 10 (TC.CM.SM.SA) with phage epsilon in group E Salmonella . The R 21 (TC) factor acquired transmissibility by the normal conjugal process when group E Salmonella strains harboring R 21 (TC) factor were infected with wild‐type F or R 16 (CM) factor. This transmissibility at high frequency was accounted for by the formation of the recombinant F TC and R 10 (CM) TC factors. The F TC and R 16 (CM) TC factors were genetically the same as the original F and R 16 (CM) factors, except for the ability to confer TC resistance. In the transduction of F TC factor with phage P1, a d F TC ( d : defective) factor was obtained that was defective in many F properties, such as the ability to introduce host chromosome and produce male substance, but was capable of transducing TC resistance ( d F TC ‐infection) at low frequency.