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Studies on the Tuberculin Reactivity of Tuberculin‐Active Peptide
Author(s) -
Someya Shiro,
Koyama Kenjiro,
Asami Nozomu,
Kataoka Tetsuo,
Yamamura Yuichi
Publication year - 1966
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1966.tb00311.x
Subject(s) - bacilli , tuberculin , potency , guinea pig , tuberculosis , medicine , tuberculin test , immunology , virology , microbiology and biotechnology , in vitro , biology , pathology , bacteria , biochemistry , genetics
A comparative study of the tuberculin potency and reactivity to TAP and PPD‐S was made in humans and guinea pigs. A comparison of reactions elicited by TAP and PPD‐S was made in two groups of guinea pigs previously inoculated with killed bacilli or with living bacilli. The tuberculin reactions produced by TAP and PPD‐S in human beings was studied in school children from rural districts. These children were divided randomly into three groups and each group was given a different amount of TAP and PPD‐S. The results obtained are as follows: (1) While relative potency of TAP was relatively much weaker than PPD‐S in guinea pigs sensitized with tubercle bacilli, in human beings the tuberculin potency of TAP was approximately 1/2 or 1/3 that of PPD‐S. (2) There was a marked difference in the tuberculin reactivity to TAP and PPD‐S between guinea pigs immunized with killed bacilli and guinea pigs immunized with living bacilli.