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EXPERIMENTAL STUDIES ON IMMUNITY IN PERTUSSIS
Author(s) -
Kaneko Yoshinori,
Moriwaki Fumiko,
Nakahara Ryunosuke,
Someya Shiro
Publication year - 1958
Publication title -
japanese journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0021-5139
DOI - 10.1111/j.1348-0421.1958.tb00065.x
Subject(s) - public health , library science , medicine , health department , computer science , nursing
In 1947 Kendrick(1) introduced the mouse protection test by the intracerebral method into the study of the potency of pertussis vaccine. Although there has been much criticism of her method, it has been a valuable method in the study of immunity in pertussis and is being used as the potency test of pertussis vaccine. However, according to the authors' knowledge, there has been no thorough examination of the experimental data obtained by this method or of its mechanism. At the beginning of the experimental studies on pertussis the authors examined the mechanisms of this method and the results obtained are herewith reported.