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Role of H elicobacter pylori in common rosacea subtypes: A genotypic comparative study of E gyptian patients
Author(s) -
Elkhalawany Mohamed,
Mahmoud Ali,
Mosbeh AlSadat,
Abd Alsalam Fatma,
Ghonaim Noha,
Aboubakr Amany
Publication year - 2012
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2012.01675.x
Subject(s) - rosacea , helicobacter pylori , caga , gastroenterology , medicine , genotype , etiology , dermatology , biology , gene , biochemistry , virulence , acne
Helicobacter pylori was incriminated as an etiological factor of rosacea. However, there is still controversy about this association. We conducted a comparative study in order to assess the role of H . pylori in rosacea patients who had dyspeptic symptoms. The study included 68 patients and 54 controls. Screening for H . pylori was performed and positive cases were referred for gastric endoscopy. The inflammatory response and bacterial density were evaluated in gastric biopsy. H . pylori vacA alleles, cagA and iceA genotypes were assessed by polymerase chain reaction. We found that 49 rosacea (72%) and 25 controls (46.3%) were infected with H . pylori . Thirty‐one rosacea cases were papulopustular ( PPR ) while 18 were erythematotelangiectatic ( ETR ). Gastric ulceration was higher in PPR cases (38.7%) than ETR (11.1%) and controls (12%). A significant inflammatory reaction was observed more in PPR cases (74.2%) compared with 44.4% in ETR ( P = 0.04) and 44% in controls ( P = 0.02). Analysis of H . pylori genotypes revealed that vacA s1m1 was more identified in PPR cases (54.8%) compared with 22.2% in ETR ( P = 0.03) and 16% in controls ( P = 0.003). There was a significant elevation of cagA / vacA s1m1 positivity in PPR cases. After the eradication regimen of H . pylori , a significant improvement ( P < 0.05) was observed in 15 out of 27 PPR cases (55.6%) compared with three out of 17 ETR (17.6%). We concluded that H . pylori has a significant role in rosacea patients who had dyspeptic symptoms. The PPR type is more influenced by H . pylori and this is regarded as being because of certain virulent strains that increase the inflammatory response in gastric mucosa and also in cutaneous lesions.