Premium
Therapeutic effectiveness of botulinum toxin type A based on severity of palmar hyperhidrosis
Author(s) -
ITO Keiko,
YANAGISHITA Takeshi,
OHSHIMA Yuichiro,
TAMADA Yasuhiko,
WATANABE Daisuke
Publication year - 2011
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2011.01214.x
Subject(s) - sweat , hyperhidrosis , medicine , botulinum toxin , surgery , anesthesia
A dose of 60 units (U) of botulinum toxin type A (BT‐A) has been confirmed to have efficacy for patients with palmoplantar hyperhidrosis. However, the effectiveness of this dose is limited in severe cases defined as sweat production of 2 mg/cm 2 per min or more (measured by the ventilated capsule method) and a Hyperhidrosis Disease Severity Scale (HDSS) grade of 3 or 4. An increased dose of 90 U of BT‐A was found to reduce sweating for approximately 7 months. In a comparison of patients with sweat production of more than 2.5 mg/cm 2 per min and an HDSS grade of 4 and patients with sweat production of 2.5 mg/cm 2 per min or less and an HDSS grade of 3, there was no difference in the reduction of sweat production at 5 months, but the duration of the reduced sweating was shorter for the former group. This suggests that there are limits to the efficacy of BT‐A for severe forms of the disease with sweat production of more than 2.5 mg/cm 2 per mL.