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Langerhans cell histiocytosis treated with narrow‐band ultraviolet B
Author(s) -
AIHARA Michiko,
HASEGAWA Toshio,
OKUYAMA Yasuhiro,
HIRUMA Masataro,
IKEDA Shigaku
Publication year - 2011
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2010.00959.x
Subject(s) - langerhans cell histiocytosis , histiocyte , erythema , dermis , medicine , pathology , histiocytosis , dermatology , radiation therapy , ultraviolet b , langerhans cell , radiology , antigen , immunology , disease
A 58‐year‐old man had widespread multiple erythemas that had been untreated for 20 years. The cutaneous lesions increased in size for a year. Histopathological examination revealed increased number of large, dysplastic, histiocytic cells in the dermis; most of these cells tested positive for Langelin, CD1a and S‐100 staining. The patient was diagnosed with Langerhans cell histiocytosis (LCH) and treated with narrow‐band ultraviolet B (NB‐UVB) radiation. The erythema improved after treatment, but the tumor remained. Therefore, the tumor was surgically excised. NB‐UVB therapy might be effective for the treatment of superficial lesions, but not tumoral lesions of LCH.