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Stevens–Johnson syndrome induced by acetazolamide
Author(s) -
HER Young,
KIL Min S.,
PARK Ju H.,
KIM Chul W.,
KIM Sang S.
Publication year - 2011
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2010.00921.x
Subject(s) - acetazolamide , toxic epidermal necrolysis , medicine , sulfonamide , carbonic anhydrase inhibitor , carbonic anhydrase , dermatology , chemistry , biochemistry , enzyme , stereochemistry
Acetazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous patients. Stevens–Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) associated with acetazolamide treatment has been diagnosed in Japanese, Japanese‐American and Indian patients. Herein, we report the second Korean case of SJS‐TEN associated with acetazolamide treatment. The result of human leukocyte antigen (HLA) typing of our patient was positive for HLA‐B59. According to recent research, HLA‐B59 has been detected in SJS caused by metazolamide, which is analogous to acetazolamide. This suggests a possible relationship between genetic background and SJS‐TEN‐associated acetazolamide treatment. Theretofore, acetazolamide should be prescribed to Korean patients with the same discreet caution.