Premium
Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low‐dose warfarin
Author(s) -
OSADA ShinIchi,
KIMURA Yoichi,
KAWANA Seiji
Publication year - 2010
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2009.00754.x
Subject(s) - medicine , warfarin , livedo reticularis , peripheral neuropathy , vasculitis , surgery , peripheral , vascular disease , dermis , regimen , dermatology , pathology , diabetes mellitus , atrial fibrillation , disease , endocrinology
We report herein a case of a 28‐year‐old woman with persistent livedo racemosa and recurrent ulcerations on the lower extremities. The clinical presentation, together with histopathological findings of vascular occlusion without overt vasculitis in the dermis, led to the diagnosis of livedoid vasculopathy. The patient experienced recurrence of ulcerations and developed peripheral neuropathy affecting the distal extremities during the course of treatment with sarpogrelate hydrochloride. The skin lesions and neurological symptoms improved dramatically after adding low‐dose warfarin potassium to the treatment regimen. This case suggests that administration of low‐dose warfarin is an effective therapy of choice for patients with livedoid vasculopathy.