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Extramammary Paget’s disease with intracytoplasmic lumen formation
Author(s) -
TSUNEMI Yuichiro,
SAEKI Hidehisa,
KIKUCHI Kanako,
TAMAKI Kunihiko,
SATO Shinichi
Publication year - 2009
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2009.00725.x
Subject(s) - extramammary paget's disease , apocrine , lumen (anatomy) , signet ring cell , pathology , duct (anatomy) , myoepithelial cell , malignancy , medicine , anatomy , immunohistochemistry , disease , adenocarcinoma , cancer
Extramammary Paget’s disease (EMPD) is regarded as a malignancy most likely derived from or differentiated into apocrine sweat duct and gland. The tumor cells in EMPD usually have abundant pale cytoplasm and large pleomorphic nuclei. We present a case with EMPD where the tumor included many signet ring cells, cells with intracytoplasmic lumen formation and glandular formation. This case is interesting in that the tumor included many cells with intracytoplasmic lumen formation. Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct.