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Case of autoimmune progesterone dermatitis presenting as fixed drug eruption
Author(s) -
ASAI Jun,
KATOH Norito,
NAKANO Mayu,
WADA Makoto,
KISHIMOTO Saburo
Publication year - 2009
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2009.00723.x
Subject(s) - menstrual cycle , medicine , menstruation , drug eruption , prednisolone , luteal phase , dermatology , lesion , drug , follicular phase , surgery , hormone , pharmacology
Autoimmune progesterone dermatitis is a rare disorder that presents as a cyclical cutaneous eruption during the luteal phase of the menstrual cycle. It typically occurs in women due to an autoimmune phenomenon to endogenous progesterone production. We describe a 34‐year‐old woman with an erythematous round plaque with blistering, which recurred a few days before her menstrual cycle, at the identical site on the left arm. The diagnosis of autoimmune progesterone dermatitis is made with i.d. skin testing on the affected lesion with progesterone. After the beginning of oral prednisolone (40 mg daily) therapy during menstruation, although slight recurrence appeared, the severity was significantly improved.