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Case of cutaneous Scedosporium apiospermum infection successfully treated with voriconazole
Author(s) -
MATSUMOTO Yuka,
OHI Tsunao,
NAGAI Ayako,
OHYAMA Fuminori,
OOISHI Tsuyoshi,
TSUBOI Ryoji
Publication year - 2009
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2009.00597.x
Subject(s) - scedosporium apiospermum , voriconazole , terbinafine , medicine , itraconazole , dermatology , ketoconazole , discontinuation , surgery , antifungal
We report a case of cutaneous infection due to Scedosporium apiospermum in a 75‐year‐old immunocompromised male patient who had received long‐term corticosteroid and immunosuppressant therapy for the treatment of nephrotic syndrome. The patient came to our department complaining of erythema with a number of pustules on the dorsal surface of the right hand. S. apiospermum was identified from a culture taken from the pus. After unsuccessful treatment with topical ketoconazole, oral itraconazole and oral terbinafine, the lesion quickly resolved with the daily administration of 400 mg voriconazole. No recurrence was observed despite discontinuation of voriconazole due to drug‐induced hepatitis. Voriconazole holds out the promise of an effective treatment for invasive Scedosporium infection.