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Transition of psoriasiform drug eruption to psoriasis de novo evidenced by histopathology
Author(s) -
YAMAMOTO Mayuko,
IKEDA Mitsunori,
KODAMA Hajime,
SANO Shigetoshi
Publication year - 2008
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2008.00558.x
Subject(s) - psoriasis , histopathology , medicine , drug , exacerbation , dermatology , immunohistochemistry , pathology , immunology , pharmacology
Drug reaction can be one of the triggering factors either for exacerbation of pre‐existing psoriasis or precipitation of psoriasis de novo. Herein, we report a case with psoriasiform drug eruption due to pravastatin, but it relapsed after discontinuance of the drug. Serial investigation of the histopathology and immunohistochemistry with anti‐signal transducer and activator of transcription 3 (STAT3) revealed drug reaction‐associated lesions intermingled with psoriasiform changes, which later predominated, suggesting a conversion into psoriasis de novo.