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Relation between elevated high‐sensitivity C‐reactive protein and anti‐mitochondria antibody in patients with systemic sclerosis
Author(s) -
OHTSUKA Tsutomu
Publication year - 2008
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2008.00418.x
Subject(s) - medicine , inflammation , gastroenterology , antibody , systemic inflammation , c reactive protein , connective tissue , connective tissue disease , etiology , immunology , pathology , autoimmune disease
Systemic sclerosis (SSc) is a systemic connective tissue disease of unknown etiology which presents immunological, vascular and connective tissue abnormalities. C‐reactive protein (CRP) has been used for the evaluation of inflammation in patients with infection and inflammatory diseases. Recently, high‐sensitivity CRP has been shown to reflect mild and/or moderate inflammation for the prognosis of ischemic heart disease. High‐sensitivity CRP was measured for the evaluation of mild and/or moderate inflammation in SSc. Forty SSc patients (male : female, 7:33; age, 16–78 years; mean, 61.9 years) were studied. High‐sensitivity CRP was measured with a nephelometric assay. The detection limit was 0.0036 mg/dL, linearity from 0.015–1.5 mg/dL. The distribution of high‐sensitivity CRP showed 26 cases (65.0%) low, three cases (7.5%) mild, four cases (10.0%) moderate, four cases (10.0%) high and three cases (7.5%) highest. The occurrence rate of anti‐mitochondria antibody in high‐sensitivity CRP elevated SSc patients (8/14, 57.1%) was significantly elevated compared with that of high‐sensitivity CRP low SSc patients (3/26, 11.5%) ( P < 0.01). These results led us to the conclusion that elevated high‐sensitivity CRP shows relation to the occurrence of anti‐mitochondria antibody.